Cyfra 21-1

Cyfra 21-1 is a tumor marker, which is mainly determined in patients with a specific form of lung cancer. Very rarely, the value can be increased even in benign diseases.

Cyfra 21-1

CYFRA 21-1 serves as a tumor marker for certain cancers. Increased readings are also found in some benign diseases. Read here what CYFRA 21-1 is exactly, when to determine the laboratory value and what changed readings can mean!

Product Overview

CYFRA 21-1

  • What is CYFRA 21-1?

  • When will the CYFRA 21-1 value be determined?

  • When is the CYFRA 21-1 value too low?

  • When is the CYFRA 21-1 value too high?

What is CYFRA 21-1?

CYFRA 21-1 is the abbreviation for cytokeratin 19 fragment. Cytokeratins are proteins that contribute to the stabilization and shape of a cell. There are 20 known cytokeratins. Cytokeratin 19 is found mainly in the capillaries (epithelia) of the bronchial mucosa. In the blood one can measure a fragment of cytokeratin 19, the cytokeratin 19 fragment (= CYFRA 21-1).

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When will the CYFRA 21-1 value be determined?

CYFRA 21-1 is the most important tumor marker in a specific type of lung cancer, non-small cell lung cancer. It is determined to diagnose this form of lung cancer, to control the course of the disease and therapy, and to assess the success of therapy.

The CYFRA 21-1 value is also determined in other cancers, such as bladder cancer and some benign diseases.

When is the CYFRA 21-1 value too low?

A downward deviation is not medically significant.

When is the CYFRA 21-1 value too high?

In healthy adults, serum CYFRA 21-1 levels are below 3.0 nanograms per milliliter (ng / ml). For certain cancers and some benign diseases, however, the reading may be elevated, such as:

  • Lung cancer (especially non-small cell lung carcinoma)
  • bladder cancer
  • Pneumonia
  • Diseases of the gastrointestinal tract
  • gynecological diseases
  • urological diseases


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