The sirs is a severe, inflammatory reaction of the body to an external influence. Find out more about the criteria of a sirs!


SIRS is the medical term for a severe inflammatory reaction of the body to an external influence. Systemic inflammatory response syndrome may be caused by pathogen toxins as well as serious injuries or burns. Due to the massive reaction, the body tries to ward off damage, but damages itself. Read all the important information about SIRS here!

ICD codes for this disease: ICD codes are internationally valid medical diagnosis codes. They are found e.g. in doctor's letters or on incapacity certificates. R65

Product Overview


  • SIRS or sepsis?

  • SIRS criteria:

  • SIRS-treatment:

SIRS or sepsis?

We speak of a SIRS (Systemic inflammatory response syndrome), when it comes to an inflammatory reaction of the entire body without a specific pathogen can be detected as a trigger or is suspected. If, on the other hand, it is possible to detect a pathogen in the blood responsible for the reaction, this is called sepsis. The distinction is important in order to make therapy decisions. In the treatment of SIRS and sepsis, it is important to remedy the underlying problem.

An entire body noninfectious inflammatory response can be triggered by many factors. These include:

  • burns
  • injury
  • large organ damage
  • severe allergic reactions (anaphylaxis)
  • Organ inflammation such as pancreatitis.
  • heavy bleeding
  • Undersupply of tissue or organs with oxygen (ischemia), e.g. in a stroke or heart attack

SIRS criteria:

To be considered SIRS (systemic inflammatory response syndrome), at least two of the following four SIRS criteria must be met:

  • Fever (-38° C) or hypothermia (-36° C), rectally, or via catheter probe within a blood vessel or the bladder measured
  • accelerated heart rate (tachycardia) to at least 90 beats per minute
  • fast breaths (tachypnea) with more than 20 breaths per minute or hyperventilation (measurable by CO2Content in the blood)
  • increased white blood cells in the blood (leukocytosis: ≥12000 / μL) or decreased (leukopenia: ≤4000 / μL)


Primary is attempted in the treatment of SIRS, to stabilize the circuit with infusions and optionally vasoconstrictor agents (vasopressors). In addition to supplementary standard therapies such as thrombosis prophylaxis and pain management, must also be considered surgery if the cause of the SIRS for example, is an organ damage or burn. Because for the sustainable treatment of a SIRS it is important to detect its trigger and, if possible, switch it off. The prognosis of SIRS depends on its cause, the general health of the patient and a possibly existing organ failure.

These laboratory values ​​are important

  • leukocytes

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